Alteration of baroreceptor reflex in the rat four-vessel occlusion model of cerebral ischemia
نویسندگان
چکیده
منابع مشابه
Cerebral Blood Flow in the Four-Vessel Occlusion Rat Model
are most likely a result of MCA occlusion. For most old rats, the thicker skull requires more drilling, and connective tissue about the vessel presents more resistance to dissection of the MCA making hemorrhage more likely than in younger rats. While the smaller lesions in older rats (734-852) are larger (p < 0.05) than for the younger rats (752-842), the size difference may be due to more surg...
متن کاملCerebral blood flow in the four-vessel occlusion rat model.
are most likely a result of MCA occlusion. For most old rats, the thicker skull requires more drilling, and connective tissue about the vessel presents more resistance to dissection of the MCA making hemorrhage more likely than in younger rats. While the smaller lesions in older rats (734-852) are larger (p < 0.05) than for the younger rats (752-842), the size difference may be due to more surg...
متن کاملCerebral ischemia produced by four-vessel occlusion in the rat: a quantitative evaluation of cerebral blood flow.
Cerebral ischemia was produced in the rat by simultaneous occlusion of the vertebral and carotid arteries according to the method of Pulsinelli and Brierley (Stroke 10: 267, 1979). Local cerebral blood flow (CBF) was determined by polarographic and autoradiographic techniques. Hydrogen-clearance measurements showed that mean CBF fell in four monitored regions of the hemispheres to between 0.11 ...
متن کاملResearch Paper: Optimization of Transient Focal Cerebral Ischemia Model by Middle Cerebral Artery Occlusion
Introduction: Cerebral ischemia is one of the most common causes of death in human populations in the industrial communities. The need for animal models is inevitable to study the pathophysiology and treatment of cerebral ischemia in human. The current study aimed at evaluating the strengths and weaknesses of different techniques used to create ischemia in previous studies and optimizing the tr...
متن کاملA new model of bilateral hemispheric ischemia in the rat--three vessel occlusion model.
A new model of bilateral hemispheric ischemia was created in the rat by occluding the common carotid arteries and the basilar artery; this resulted in consistent and severe impairment of the cerebral blood flow. The procedure for producing this model is described, and the results of EEG and autoradiography obtained by this model are compared to those obtained by the four-vessel occlusion model.
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1990
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)55480-4